Now you've gone and opened up a can of worms (favourite powders), lol. A powder should be choosen because it produces the desired results (accuracy, cleanliness, velocity etc.). Since you're trying to replicate a defensive type load CFE will do just fine. I'd also get a lb of something a little faster just to try (231/HP-38, Titegroup, Sport Pistol etc.). Every powder has its own set of pros and cons but at the end of the day most powders are at least serviceable.
We cannot carry in Canada, so take this advice with a grain of salt, but I would never use reloads in a defensive situation.