You can definitely compete in major with the 38 GT right out of the box and the issue with the 9mm is not being competitive, but durability shooting Major. If you keep it right around 165-170 you should be fine with most of the popular powders, but if you want a safety margin for major matches, you'll be limited to just a handful of powders and need careful load development.
I think it is possible to shoot tens of thousands of 175-180 pf 9mm through a v12, but like I said, you'd most likely be using a case full of hard to get/expensive VV powder and it would be pretty violent.
ETA: this is all just my conservative speculation and you might be fine for 100k rounds using 8+ gr of Autocomp.