One thing to remember about powder for pistol loads is for popular minor power factor stuff, you're going to get upwards of if not more than 2,000 rounds per pound of powder, and availing yourself of that keg price once you settle on something. If VV winds up being 35 bucks per pound for you, that's not even two cents per round, compared to primers being twice that, and inexpensive coated bullets being 7-8 cents a round.
If your goal is the minimum price per round possible irrespective of other factors, which is not necessarily the direction most competitors take, using a light-for-caliber bullet has more savings to offer.
All that said, I use Titegroup in 9mm and .40 because it is accurate, soft-shooting, clean-metering, and available. It simply happens to be inexpensive, which is icing on the cake. .45, I lose zero sleep on my love of N310, since on lead alone I'm already chucking dimes downrange.
Rifle, on the other hand, if you shoot a ton, that keg of powder doesn't go nearly as far