Opinions vary, I suppose, but I advocate a small amount of blue loctite on every screw on a S&W revolver (except the sight adjustment screws, obviously), including the cylinder release screw and the small screw that holds the rear sight assembly in place. Once everything is set up correctly on a gun, I tighten everything down very firmly with well-fitting screwdriver bits, and leave it alone. There is really no reason to take the gun apart unless there is a problem that needs fixing--which will be a pretty rare occurrence if you don't dick around with stuff. Most of the problems people have with revolvers are self-induced.