The Simpsons are my favorite (with Futurama as a close second).
Some cool quotes:
Lionel Hutz: Well, he's kind of had it in for me ever since I accidentally ran over his dog. Actually, replace "accidentally" with "repeatedly," and replace "dog" with "son."
Homer: [drunk] Look, the thing about my family is there's five of us. Marge, Bart, Girl Bart, the one who doesn't talk, and the fat guy. How I loathe him.
Ralph: [whispering] Lisa, what's the answer to number seven?
Lisa: [whispering] Sorry, Ralph. That would defeat the purpose of testing as a means of student evaluation.
Ralph: [pauses] My cat's name is Mittens
Grandpa: My Homer is not a communist. He may be a liar, a pig, an idiot, a communist, but he is not a porn star.