Absolutely--for maximum ignition reliability, it's important to have centered primer hits. Several problems can cause this symptom (e.g., yoke that's not straight, carry-up problem, cylinder stop problem, worn center-pin hole, etc.). Also, if it's hitting the primers off-center the bullets may not be well-aligned when they enter the forcing cone. All of these possible causes can be corrected, some more easily and inexpensively than others....