I do just that. I load all of my rounds with Bullseye powder 45 ACP, 40 S&W, and 9mm. I started using Bullseye for 45 ACP and really liked it. It is cheap, meters well and requires a small charge to get the velocities required.
As to being dirty, if the round is not properly constructed it will be very dirty. There needs to be a good tight crimp or some other way to get the pressures up. I can run 300 rounds through my gun with Bullseye and compare it to my friend who shoots the same amount of rounds loaded with Tightgroup, my gun just looks sooty while the Tightgroup gun look very dirty with a greasy like film everywhere inside the gun.
It is not the perfect powder for high-pressure cartridges like 40 S&W & 9mm but it can be used within reason. Just watch for pressure signs and work up to where you want to be.