Thanks for the welcome Kevinc and thanks to all for your input.
I suspected this topic had been discussed, but my search efforts usually result in 20 gazillion hits or none
I did mention this problem to one of the shooters at our indoor league who has a masters in math. She recommended an experimental approach - record the standard deviation after every 5 rounds and when the SD "settles down" and approaches a limit, you have reached a practical sample size. Of course, it is yet to be determined if the SD will "settle down" in what I regard as a practical number of rounds to expend in trying to measure one load.
Anyhow, based on the topic posts and my unscientific gut feel, I'll use 20-30 rounds per load at my next chrono session and may try the suggested experiment.
DVC
RobT