I personally am a big fan of my recently aquired tanfoglio. I have large hands but prefer small grips. The full sized tanfo is the first double stack 45 I have ever picked up that doesn't feel like a 2x4 to me.
All that said I am a firm believer in the right tool for the job,. I don't think a full race pistol in the nightstand is the best idea. To many bells and whistles to complicate things in a tense situation.