When I bought my sights, no info was available at the time (2 months ago) so I'll throw in my experience. Buy the prescribed sights as stated by Dawson. I have the blacked-out .245 rear with the .145 notch and the .180 tall F/O front with the .105w. This sight combo was made to not co-witness with a red-dot. I don't have a RDS so I wouldn't know is it holds true. Sometime down the line when I get to buy one I'll edit this post.
I have the M&P40 CORE in with the 5" barrel. And after hearing mixed reports and such in my research (ENOS, MP-Pistol, S&W Forum, ARFcom, etc...) with the other long slide M&Ps I just called Dawson directly and asked what they recommended. They said to buy the sights as prescribed. DP has been doing this for a while so I trusted them. The sights were developed to shoot POA/POI. So in this case right behind the F/O. Which is consistent with my previous M&P9/40 FS.
I got the sights and had them installed by my local gunsmith who also made sure it hit POA/POI. Which it does at 20 yards. I can get shots standing free handed about a 2inch group in the head box of a IDPA/USPSA target. I know it's conjecture for you, but I guess what I'm saying is that DP was right. I wanted to shoot my CORE in IDPA SSP/ESP and USPSA Production/Limited/L10. Mileage may vary but that's what I did. Really had nothing to lose. If it wasn't hitting where I was aiming then I follow the formula and take adcantage of the Dawson Guarantee and get a new front-sight. I hope this helps.