Stick your finger out in front of your face. If you can focus and see your finger print then I would assume there is nothing physically preventing you from focusing on your front sight. I believe as do many others that being able to shoot with both eyes open is an advantage. But I know some great shooters that only use one eye. Again you must decide that you want to do it then practice. There is no magic answer here. Whether you use tape on your glasses, squint or use a dot it all takes time and effort. I would highly suggest that you do this practice in dry fire first.