I use a Super 1050 for a variety of calibers: 223, 308, 9mm, 40 S&W, 10mm, 45 ACP, 44 Spl/Mag. I only have one tool head and it takes me about 45 minutes to swap from one caliber/primer size to another. It's a little quicker if using the same primer size. I use a lot of surplus 308, 223 and 9mm so it's nice to have the swage capability. When I first got the 1050 I had a number of 5 gallon buckets of 308 and 223 to process. When I load I will set up for one caliber and plan on loading at least 1000, preferably more, rounds of that caliber to make it worth changing over. When I process the rifle brass I usually tumble the brass, size, swage and trim/size (using a Dillon RT1200). When I reload rifle I use a spacer between the lock ring and tool head so I'm not fully sizing the brass.
I'm also using a Mr. Bullet Feeder that helps speed up the operation. What slows down the process is filling primer tubes so make sure you pick up plenty of extras. Last week I was loading some 380 on my 550 and it sure seemed like a slow process.