I just upgraded from a 650 to the 750. My biggest issue I had with the 650's primer system is that I had issues with occasional primer seating sideways issue and I was just generally annoyed with the always-on primer advancing (I know this can be "fixed" with a primer stop switch aftermarket), but I had somebody who was looking to get a 650 so I offered mine for sale and just stepped up to the 750.
IMO the primer system on the 750 is much, much better. No more issues with sideways primers or primer disc failing to advance due to some hangup in the system. It just works. Not sure if it's because the 750 I have is brand new and my 650 I bought used, but I just think the 750's primer system is simpler, faster to change from large to small, and is just less of a headache in general. I also do feel that the seating is more positive and produces more consistent beneath-flush seating than my old 650.