First I find what my rifle likes and is built for.
I have a 20” wilson barrel in wylde on a ar platform. I use 52g vmax with benchmark now but had used 748 before with real good results. I tried AR comp with them and was ok but they like a little heavier bullet for whatever reason.
CFE 223 works great but I am not chasing FPS and the stuff is dirty and plugs my gas tube faster.
I do use a suppressor.
Pick a bullet, build a ladder test and try the powders yourself.
YMMV