eric nielsen Posted October 6, 2008 Share Posted October 6, 2008 Almost forgot about you guys till Sandro called - AND, I had to cram this into my dome for a test tomorrow: CLINICAL ASPECTS OF NITRIC OXIDE SYNTHASE iNOS (NOS induced expression in macrophage) Essential for tumoricidal and bacterialicidal functions of macrophage. Overproduction implicated in septic/cytokine induced circulatory shock. eNOS (endothelial form of NOS) eNOS has critical role in maintaining blood vessel tone especially in the arterioles. Overproduction can result in hypertension, thrombosis and Atherosclerosis. However, application as a gas is beneficial in treatment of pulmonary arterial hypertension. It has also been used for treatment of acute respiratory distress syndrome. nNOS (neuronal form of NOS) Elimination of this gene in mice (knockout mice) show loss of control of intestinal muscles. Mice also show resistance to ischemic injury which produces vascular stroke. Okay, back into the hole I crawled out of. Link to comment Share on other sites More sharing options...
Miranda Posted October 6, 2008 Share Posted October 6, 2008 hmmmm let me see if I have this right eNOS is a gas... it can help reduce typertension I hope Brian doesn't get wind on this. because he might brand it and charge us. Brian eNOS its a gassss! available in the forum. lose all your tensions. Link to comment Share on other sites More sharing options...
iainmcphersn Posted October 7, 2008 Share Posted October 7, 2008 Jumping Jack Flash, it's a gas, gas, gas! Link to comment Share on other sites More sharing options...
Sandro Posted October 7, 2008 Share Posted October 7, 2008 a gas is a state of matter, consisting of a collection of particles (molecules, atoms, ions, electrons, etc.) without a definite shape or volume that are in more or less random motion. Yeah, we all need eNOS. Link to comment Share on other sites More sharing options...
Sharyn Posted October 7, 2008 Share Posted October 7, 2008 (edited) We use Nitric Oxide (iNO) quite frequently in the NICU for PPHN... I love telling the Dads that their baby is being treated with "the inhaled form of Viagra." The various reactions are priceless. Edited October 7, 2008 by Sharyn Link to comment Share on other sites More sharing options...
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