What I did to start was load the 140 Gn RNFP Acme bullet with the E3 from 4.0 Gn to 5.8 Gn in 0.2 Gn increments, 5 loads each. They averaged respectively, 1039/1055/1082/1111/1146/1175/1217/1231/1274/1285. All of which seem to be acceptable speeds for the 40 SW. No signs of primer flattening or blow outs, or blow by's. Used a 40 SW M&P 2.0 with a 5" barrel.
So I went on with 9mm in two different weight bullets, and came up with comparable results! 115 Gn Missouri RN bullet with the E3 @ 3.3 Gn to 4.2 Gn, giving velocities of 1073 fps to 1213. Then a 125 Gn RN Acme bullet with E3 @ 3.2 Gn to 4.2 Gn, giving velocities from 1020 through 1200 fps, same results with the primers. That was out of a Beretta 92 FS with a 4 7/8" barrel.
I went on to 45 ACP with the same 5 shot load, or is it string, sequence. 175 Gn Acme SWC with E3 @ 4.0 Gn to 4.4 Gn gave me 664 to 1172 FPS. That was a Tisas 1911 A1 with 5" barrel. I loaded up a test round of 185 Gn'ers but the sun went down on the old Pawnee!
I should clarify that the 9mm and 45 ACP were loaded in 0.1 Gn increments.