Certainly. To be honest I dont know where to start, since mine and many others have been so reliable. My Open Glock 17 runs the best with a OEM recoil spring and rod, I have tried 11lb through 16lb springs and it just feels the best with an OEM rod and spring. Then I took a bit of time to work up a good load. I am currently running 8.0gr of Hs6. I have settled on Berry's 124gr HBFP, it's a great bullet, loaded to a COL of 1.1025. This particular bullet, with its hollow base, increases internal case volume a small amount, enough to show less pressure signs compared to a standard bullet profile. It is very important to load quality ammo and then check each individual round before practice or matches. Making consistent ammunition will save a lot of headaches with reliability.
Using a good barrel such as KKM or Lonewolf is also key to a reliable gun. I run a KKM but either one of these will have a fully supported and a throated chamber to allow long COL (overall length).
The Carver Custom Optic mount, no matter which optic you choose, the mount adds a good amount of weight up front and holds zero 100%. Its rock solid. I am also using a 4 port Carver Custom Compensator and have tried many others, but settled back on Carver's 4 port comp, I love it, it shoots very flat.
Thanks.