I was loading 4.6 grains of Titegroup with Xtreme 180 grain rnfp to make major out of my G35. Groups were bad and many bullets tumbled. I ended up switching to AA#5 and had much better results.
I use Titegroup for minor loads and have been VERY happy. I switched to Blue Bullets and load 3.2 grains for .40 production and IDPA. Super soft and fantastic accuracy.